ANTIMALARIAL ACTIVITY AND CYTOTOXICITY OF EVODIA-FATRAINA STEM BARK EXTRACTS

被引：10

作者：

RATSIMAMANGAURVERG, S

RASOANAIVO, P

RAKOTORATSIMAMANGA, A

LEBRAS, J

RAMILIARISOA, O

SAVEL, J

COULAUD, JP

机构：

[1] INST MALGACHE APPL, ANTANANARIVO 101, MADAGASCAR

[2] HOP CLAUDE BERNARD, INST MED & EPIDEMIOL TROP & AFRICAINES, DEPT BIOL PARASITAIRE,INSERM,U13, F-75877 PARIS, FRANCE

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1991年 / 33卷 / 03期

关键词：

EVODIA-FATRAINA; ANTIMALARIAL ACTIVITY; MADAGASCAR; PLASMODIUM;

D O I：

10.1016/0378-8741(91)90082-O

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Stem bark extracts of Evodia fatraina (Rutaceae) were tested for antimalarial activity in vitro on Plasmodium falciparum using an isotopic semi-microtest and in vivo on Plasmodium berghei in mice. Ethyl acetate extract showed moderate antimalarial activity in vitro (IC50 = 8.5-mu-g ml-1). However, ethanolic extract exhibited significant potency in vivo (65% suppression of parasitaemia). Moreover, low toxicity against HeLa cells and L 929 fibroblasts was observed with ethanolic extract (IC50 = 95-mu-g ml-1 and 60-mu-g ml-1, respectively).

引用

页码：231 / 236

页数：6

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