PORPHYRIA-CUTANEA-TARDA AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR CHRONIC MYELOGENOUS LEUKEMIA

被引：15
|
作者：
GUYOTAT, D
NICOLAS, JF
AUGEY, F
FIERE, D
THIVOLET, J
机构：
[1] HOP EDOUARD HERRIOT,DERMATOL CLIN,F-69374 LYONS 08,FRANCE
[2] HOP EDOUARD HERRIOT,UNITE GREFFES MOELLE OSSEUSE,F-69374 LYONS 08,FRANCE
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 1990年 / 34卷 / 01期
关键词：
cytomegalovirus infection; hepatic porphyria; immune deficiency;
D O I：
10.1002/ajh.2830340115
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A case of porphyria cutanea tarda (PCT) occurring after bone marrow transplantation (BMT) is reported. A 43‐year‐old male with chronic myelogenous leukemia received an human leukocyte antigen (HLA)‐identical allogeneic transplantation with T‐cell depleted marrow. Because of graft rejection, a second transplant was performed 4 months later. A grade II acute graft‐ vs.‐host disease and a cytomegalovirus (CMV) infection were subsequently observed. Two years after the second transplant, cutaneous symptoms of PCT with typical biochemical abnormalities developed. Liver biopsy revealed signs of hepatitis with iron overload. CMV was isolated from liver tissue. The possible roles of underlying disease, BMT, and CMV liver disease are discussed in view of the recently reported cases of PCT in patients with AIDS or hematological disorders. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码：69 / 70
页数：2
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