STRUCTURE AND PHYSIOLOGY OF PHOTORECEPTOR CGMP-GATED CATION CHANNELS

被引:1
|
作者
HAYNES, LW
机构
关键词
D O I
10.1017/S0140525X00039315
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
The primary sequence of two subunits of the rod and one subunit of the cone cGMP-gated channel have been described, but describing how structure determines function is only just beginning. The discovery that the affinity of the rod channel for its agonist can be modulated indicates that the relationship between intracellular cGMP and the channel's open probability (current) during the course of the photoresponse may be more complex than previously thought.
引用
收藏
页码:476 / 477
页数:2
相关论文
共 50 条
  • [1] Modulation of cone photoreceptor cGMP-gated channels
    Haynes, LW
    Stotz, SC
    BIOPHYSICAL JOURNAL, 1996, 70 (02) : MAMK7 - MAMK7
  • [2] AFFINITY PURIFICATION OF THE PHOTORECEPTOR CGMP-GATED CATION CHANNEL
    HURWITZ, R
    HOLCOMBE, V
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (13) : 7975 - 7977
  • [3] Modulation of synaptic function by cGMP and cGMP-gated cation channels
    Barnstable, CJ
    Wei, JY
    Han, MH
    NEUROCHEMISTRY INTERNATIONAL, 2004, 45 (06) : 875 - 884
  • [4] Focus on Molecules: Rod photoreceptor cGMP-gated cation channel
    Sarfare, Shanta
    Pittler, Steven J.
    EXPERIMENTAL EYE RESEARCH, 2007, 85 (02) : 173 - 174
  • [5] MODULATION OF THE CGMP-GATED CHANNELS OF ROD PHOTORECEPTOR CELLS BY CALMODULIN
    HSU, YT
    MOLDAY, RS
    MOLECULAR BIOLOGY OF THE CELL, 1992, 3 : A195 - A195
  • [6] Developmental expression of the rat rod photoreceptor cGMP-gated cation channel
    Chiang, RK
    Barnstable, CJ
    VISUAL NEUROSCIENCE, 1998, 15 (05) : 823 - 829
  • [7] Muller cells express functional cGMP-gated cation channels
    Kusaka, S
    Dabin, I
    Barnstable, CJ
    Puro, DG
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996, 37 (03) : 665 - 665
  • [8] PRIMARY STRUCTURE AND CHROMOSOMAL LOCALIZATION OF HUMAN AND MOUSE ROD PHOTORECEPTOR CGMP-GATED CATION CHANNEL
    PITTLER, SJ
    LEE, AK
    ALTHERR, MR
    HOWARD, TA
    SELDIN, MF
    HURWITZ, RL
    WASMUTH, JJ
    BAEHR, W
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (09) : 6257 - 6262
  • [9] ROD AND CONE PHOTORECEPTOR CELLS EXPRESS DISTINCT GENES FOR CGMP-GATED CHANNELS
    BONIGK, W
    ALTENHOFEN, W
    MULLER, F
    DOSE, A
    ILLING, M
    MOLDAY, RS
    KAUPP, UB
    NEURON, 1993, 10 (05) : 865 - 877
  • [10] Modulation of rod, but not cone, cGMP-gated photoreceptor channels by calcium-calmodulin
    Haynes, LW
    Stotz, SC
    VISUAL NEUROSCIENCE, 1997, 14 (02) : 233 - 239