GENERATION OF INTERLEUKIN-8 BY PLASMIN FROM AVLPR-INTERLEUKIN-8, THE HUMAN FIBROBLAST-DERIVED NEUTROPHIL CHEMOTACTIC FACTOR

被引：54
|
作者：
NAKAGAWA, H
HATAKEYAMA, S
IKESUE, A
MIYAI, H
机构：
[1] Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, 930-01, Sugitani
来源：
FEBS LETTERS | 1991年 / 282卷 / 02期
关键词：
INTERLEUKIN-8; FIBROBLAST; PLASMIN; NEUTROPHIL CHEMOTACTIC FACTOR;
D O I：
10.1016/0014-5793(91)80526-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.
引用
收藏
页码：412 / 414
页数：3
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