PIG-LIVER ESTERASE CATALYZED HYDROLYZES OF RACEMIC ALPHA-SUBSTITUTED ALPHA-HYDROXY ESTERS

被引：51

作者：

MOORLAG, H

KELLOGG, RM

KLOOSTERMAN, M

KAPTEIN, B

KAMPHUIS, J

SCHOEMAKER, HE

机构：

[1] STATE UNIV GRONINGEN,DEPT ORGAN CHEM,NIJENBORGH 16,9747 AG GRONINGEN,NETHERLANDS

[2] DSM RES & PATENTS,BIOORGAN CHEM SECT,6160 MD GELEEN,NETHERLANDS

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 23期

关键词：

D O I：

10.1021/jo00310a020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pig liver esterase catalyzed hydrolyses of some ɑ-substituted a-hydroxy esters give product acids and recovered esters in 9-94% enantiomeric excess. The observed enantiomeric selectivity could be rationalized using a recently proposed active site model, which proved to be of predictive value. © 1990, American Chemical Society. All rights reserved.

引用

页码：5878 / 5881

页数：4

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