GLUTATHIONE AND GLUTATHIONE LINKED ENZYMES IN HUMAN SMALL-CELL LUNG-CANCER CELL-LINES

被引：27
|
作者：
SHARMA, R [1 ]
SINGHAL, SS [1 ]
SRIVASTAVA, SK [1 ]
BAJPAI, KK [1 ]
FRENKEL, EP [1 ]
AWASTHI, S [1 ]
机构：
[1] UNIV TEXAS,MED BRANCH,DEPT INTERNAL MED,DIV HEMATOL & ONCOL,GALVESTON,TX 77555
来源：
CANCER LETTERS | 1993年 / 75卷 / 02期
关键词：
CISPLATIN; SMALL CELL LUNG CANCER; DRUG RESISTANCE; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE;
D O I：
10.1016/0304-3835(93)90195-F
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glutathione levels and several glutathione-linked enzyme activities have been variably correlated with cisplatin chemosensitivity in cultured neoplastic cells. In order to determine the relative contribution of the glutathione-linked enzymes towards mediating inherent cisplatin resistance in cancer cells, we have measured the chemosensitivity to cisplatin, glutathione levels and activities of glutathione S-transferase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase in 8 cultured human small cell lung cancer (SCLC) cell lines with widely differing cisplatin sensitivities. Of these parameters, only glutathione S-transferase activity correlated with degree of cisplatin resistance in a linear fashion.
引用
收藏
页码：111 / 119
页数：9
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