ROLES OF GLUTAMATE RECEPTORS IN LONG-TERM POTENTIATION AT HIPPOCAMPAL MOSSY FIBER SYNAPSES

被引：83
|
作者：
ITO, I [1 ]
SUGIYAMA, H [1 ]
机构：
[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,6-10-1 HAKOZAKI,HIGASHI KU,FUKUOKA 812,JAPAN
来源：
NEUROREPORT | 1991年 / 2卷 / 06期
关键词：
LONG-TERM POTENTIATION; HIPPOCAMPUS; MOSSY FIBER SYNAPSE; GLUTAMATE RECEPTOR; METABOTROPIC GLUTAMATE RECEPTOR;
D O I：
10.1097/00001756-199106000-00008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
WE have investigated the roles of glutamate (Glu) receptors in the mechanism of long-term potentiation observed in rat hippocampal mossy fiber synapses (MF-LTP). The mossy fiber responses were almost completely suppressed by ionotropic Glu receptor (iGluR) antagonists both before and after the induction of LTP. However, tetanic stimulation produced robust LTP even when the synaptic transmission was blocked postsynaptically by iGluR antagonists. In contrast, when the transmission was blocked presynaptically by Ca2+-free media, tetanic stimulation produced no LTP. D,L-2-amino-3-phosphonopropionate(D,L-AP3), a metabotropic Glu receptor (mGluR) antagonist, inhibited the induction of MF-LTP. Perfusion with ibotenate, a mGluR agonist, induced long-lasting enhancement of the mossy fiber responses without tetanic stimulation, and this ibotenate-induced potentiation was antagonized by D,L-AP3.
引用
收藏
页码：333 / 336
页数：4
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