EFFECT OF ANGIOTENSIN-II BLOCKADE ON DIETARY PROTEIN-INDUCED RENAL GROWTH

被引：7
|
作者：
SMITH, LJ [1 ]
ROSENBERG, ME [1 ]
HOSTETTER, TH [1 ]
机构：
[1] UNIV MINNESOTA,DEPT MED,DIV RENAL DIS & HYPERTENS,UMHC BOX 736,420 DELAWARE ST SE,MINNEAPOLIS,MN 55455
来源：
AMERICAN JOURNAL OF KIDNEY DISEASES | 1993年 / 22卷 / 01期
关键词：
RENIN; ANGIOTENSIN; DIETARY PROTEIN; RENAL GROWTH;
D O I：
10.1016/S0272-6386(12)70177-4
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Dietary protein provokes renal growth and synthesis of renin. Because angiotensin II (AII) has growth-promoting properties, we tested the possibility that protein-induced renal growth depends on angiotensin II. Normal adult male rats placed on a high-protein diet (50%) developed significant renal and glomerular growth over 6 days compared with rats on a low-protein diet (6%). However, neither angiotensin converting enzyme inhibition with enalapril nor angiotensin receptor antagonism with losartan influenced the degree of whole-kidney, cortical tubular, or glomerular growth. Thus, angiotensin II is not a necessary factor in dietary protein-induced renal growth in normal adult rats. © 1993, National Kidney Foundation. All rights reserved. All rights reserved.
引用
收藏
页码：120 / 127
页数：8
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