NEUROFIBRILLARY CHANGES CONFINED TO THE ENTORHINAL REGION AND AN ABUNDANCE OF CORTICAL AMYLOID IN CASES OF PRESENILE AND SENILE DEMENTIA

被引：104
|
作者：
BRAAK, H
BRAAK, E
机构：
[1] Zentrum der Morphologie, Frankfurt/Main 70, D-6000
来源：
ACTA NEUROPATHOLOGICA | 1990年 / 80卷 / 05期
关键词：
Alzheimer's disease; Amyloid; Dementia; Entorhinal region; Neurofibrillary tangles;
D O I：
10.1007/BF00294607
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cases of old-aged demented individuals exhibited abundant cortical amyloid deposits but only small numbers of neurofibrillary changes. Neuritic plaques were rare or absent. Neither Ammon's horn nor isocortex revealed sufficiently large numbers of tangles to permit the diagnosis of fully developed Alzheimer's disease. Dense accumulations of neurofibrillary tangles and neuropil threads occurred only in layer Pre-α (II) of the entorhinal region. This pattern of cortical destruction may represent a variant of Alzheimer's disease or an initial stage of this disorder. © 1990 Springer-Verlag.
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页码：479 / 486
页数：8
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