INHIBITION OF HIV REPLICATION BY TRICHOSANTHIN IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS

被引：8
|
作者：
PAN, LZ [1 ]
LEVY, JA [1 ]
机构：
[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT MED,CANC RES INST,SAN FRANCISCO,CA 94143
来源：
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 1994年 / 55卷 / 06期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0011-393X(05)80807-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In this study, trichosanthin (GLQ223(TM)), a single-chain, ribosome-inactivating plant protein, suppressed replication of multiple strains of the human immunodeficiency virus (HIV)-1 and the HIV-2UC3 strain in peripheral blood mononuclear cells (PBMCs). One strain (HIV-1SF162) was resistant to the effects of trichosanthin. At low concentrations, the drug showed no toxicity for uninfected PBMCs under treatment conditions that inhibited virus replication. The drug was most active in suppressing virus replication when added at the time of HIV inoculation. Trichosanthin has no direct effect on the virus. Different degrees of inhibition were observed when the same virus isolates were tested using PBMCs from different donors. These observations suggest that cellular factors can influence the effect of the drug and support further evaluation of trichosanthin in anti-HIV therapy.
引用
收藏
页码：718 / 727
页数：10
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