Reliability generalization (RG) is a meta-analysis that combines and synthesizes reliability coefficients from different studies to ascertain the average observed reliability across studies. An RG study was conducted on previously reported data from 16 samples of the Overexcitability Questionnaire-Two (OEQII) with a combined N of 5,275. Cronbach's alpha was found to be consistently higher on all OEQII subscales when scale variance was high and the sample consisted of adults. Sample size, gender composition of the sample, number of items from the subscale used, and location of sample (United States or a different county) had varying effects on observed alpha levels for each subscale. Suggestions are proposed for substantive research using the OEQII and for future psychometric research on the instrument.