TRANSDERMAL CONTROLLED DELIVERY OF VERAPAMIL - CHARACTERIZATION OF INVITRO SKIN PERMEATION

被引：19
|
作者：
SHAH, HS [1 ]
TOJO, K [1 ]
CHIEN, YW [1 ]
机构：
[1] RUTGERS STATE UNIV,COLL PHARM,CONTROLLED DRUG DELIVERY RES CTR,POB 789,PISCATAWAY,NJ 08855
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 86卷 / 2-3期
关键词：
VERAPAMIL; SKIN PERMEATION; HAIRLESS MOUSE SKIN; BIOLOGICAL FACTORS; PH EFFECTS; MECHANISTIC ANALYSIS;
D O I：
10.1016/0378-5173(92)90194-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The objective of this investigation was to determine the feasibility of transdermal delivery of verapamil by studying its in vitro skin permeation characteristics. Skin permeation experiments were carried out using excised skin from hairless mice mounted in an in vitro permeation system. The effects of age, sex and site of skin excised, as well as the influence of pH and of drug concentration in the donor solution on the permeation rate of verapamil were studied. Successive stripping of the stratum corneum was observed to increase the permeation rate until the stratum corneum was completely removed, suggesting that stratum corneum plays a rate-limiting role in the skin permeation of verapamil. The physico-chemical properties of verapamil, viz., diffusivity, partition coefficient and solubility, in stratum corneum and viable skin were determined based on the bilayer skin model.
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页码：167 / 173
页数：7
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