THE NOVEL MECHANISM OF INITIATION OF PICORNAVIRUS RNA TRANSLATION

被引：333
|
作者：
JACKSON, RJ
HOWELL, MT
KAMINSKI, A
机构：
[1] Department of Biochemistry, University of Cambridge, Cambridge
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 12期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0968-0004(90)90302-R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The initiation of translation of picornaviral RNAs takes place by an unusual mechanism whereby ribosomes bind directly to an internal site rather than scan the RNA from the 5'-end. This internal entry mechanism requires a 450-nucleotide segment of the picornavirus 5'-untranslated region. The ribosome binds initially to a site at the 3'-end of this segment, and then may scan the RNA to reach the authentic initiation site. This novel mechanism may be of relevance to the translation of some cellular mRNAs.
引用
收藏
页码：477 / 483
页数：7
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