HLA ANTIGENS IN BRAZILIAN PATIENTS WITH PARACOCCIDIOIDOMYCOSIS

被引：12

作者：

GOLDANI, LZ ^{[1
]}

MONTEIRO, CMC ^{[1
]}

DONADI, EA ^{[1
]}

MARTINEZ, R ^{[1
]}

VOLTARELLI, JC ^{[1
]}

机构：

[1] UNIV SAO PAULO,RIBEIRAO PRETO SCH MED,DEPT INTERNAL MED,SAO PAULO,BRAZIL

来源：

MYCOPATHOLOGIA | 1991年 / 114卷 / 02期

关键词：

PARACOCCIDIOIDOMYCOSIS; P-BRASILIENSIS;

D O I：

10.1007/BF00436427

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Eighty patients with paracoccidioidomycosis were typed for 43 HLA specificities from loci A, B, C and DR. A highly significant increased frequency of HLA-B40 (relative risk 29.2) and HLA-Cw1 (relative risk 8.8) were found in patients compared to control subjects. The frequencies HLA-A2, B7 and B21 were also increased in patients and haplotypes-B40-Cwl and -A2-B40 were positively correlated with the disease. DR antigen frequencies were not significantly altered in the patients and evidence of a protective effect was not found for any of the 43 antigens tested. These findings further support the involvement of the HLA system in the genetic susceptibility to paracoccidioidomycosis and the importance of ethnic variability in this association.

引用

页码：89 / 91

页数：3

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