LOCALIZATION OF MITOCHONDRIAL-DNA IN NORMAL AND PATHOLOGICAL MUSCLE USING IMMUNOLOGICAL PROBES - A NEW APPROACH TO THE STUDY OF MITOCHONDRIAL MYOPATHIES

被引：19
|
作者：
ANDREETTA, F
TRITSCHLER, HJ
SCHON, EA
DIMAURO, S
BONILLA, E
机构：
[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,ROOM 5-431,630 W 168TH ST,NEW YORK,NY 10032
[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT GENET & DEV,NEW YORK,NY 10032
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 1991年 / 105卷 / 01期
关键词：
ANTI-DNA; MTDNA ANTIBODY; MITOCHONDRIAL MYOPATHIES;
D O I：
10.1016/0022-510X(91)90123-O
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We have studied the usefulness of anti-DNA antibodies to detect ragged-red fibers (RRF) in muscle biopsies from patients with mitochondrial myopathies. We have found that these antibodies are excellent probes for the localization of mitochondrial DNA(mtDNA) in RRF, and for the diagnosis of depletion of mtDNA in a newly described group of fatal myopathies of infancy.
引用
收藏
页码：88 / 92
页数：5
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