MISOPROSTOL TREATMENT EXACERBATES ABDOMINAL DISCOMFORT IN PATIENTS WITH NONULCER DYSPEPSIA AND EROSIVE PREPYLORIC CHANGES - A DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY

被引：27
|
作者：
HAUSKEN, T
STENELARSEN, G
LANGE, O
ARONSEN, O
NERDRUM, T
HEGBOM, F
SCHULZ, T
BERSTAD, A
机构：
[1] LOVISENBERG HOSP,DEPT MED,OSLO,NORWAY
[2] MOLDE CTY HOSP,DEPT MED,MOLDE,NORWAY
[3] HAMMERFEST HOSP,DEPT MED,HAMMERFEST,NORWAY
[4] ASKIM HOSP,DEPT MED,ASKIM,NORWAY
来源：
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1990年 / 25卷 / 10期
关键词：
Dyspepsia; Gastric erosions; Misoprostol; Non-ulcer; Prostaglandin;
D O I：
10.3109/00365529008997630
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
One hundred and thirty-seven consecutive outpatients with non-ulcer dyspepsia (NUD) and erosive prepyloric changes (EPC) were randomly allocated to double-blind treatment with 400-μg misoprostol tablets twice daily or placebo for 4 weeks. Misoprostol had a significant worsening effect on epigastric pain, nausea, meteorism, lower abdominal pain, and diarrhoea, as compared with placebo. The fact that symptoms in patients with NUD and EPC were exacerbated by an antisecretory dose of misoprostol indicates that the symptoms are largely unrelated to gastric acid. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：1028 / 1033
页数：6
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