QUANTITATIVE LIQUID-CHROMATOGRAPHY, THERMOSPRAY TANDEM MASS-SPECTROMETRIC (LC/TSP/MS/MS) ANALYSIS OF SOME TRANQUILIZERS OF THE THIOXANTHENE GROUP IN WHOLE-BLOOD

被引：9
|
作者：
VERWEIJ, AMA [1 ]
HORDIJK, ML [1 ]
LIPMAN, PJL [1 ]
机构：
[1] MINIST JUSTICE,DEPT TOXICOL,FORENS SCI LAB,2288 GD RIJSWIJK,NETHERLANDS
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 19期
关键词：
D O I：
10.1080/10826079408013603
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A LC/TSP/MS/MS selected reaction monitoring (SRM) method in the daughter ion scan mode can be succesfully applied for the quantitative determination of members of the Thioxanthenegroup like Chlorprothixene,Flupenthixol,Thiothixene and Zuclopenthixol in whole-blood following a BondElut extraction. Detection limits as low as 100pg for Chlorprothixene varying to 2ng per injection for the other compounds were found (corresponding to 0.5 to 10ng per mL whole-blood). Sensitivity of the proposed method is of the same order of chromatographic methods with other detectors or a RIA method.
引用
收藏
页码：4099 / 4110
页数：12
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