KINETICS OF ANTIBODY-RESPONSE TO HEPATITIS-B VIRUS DETERMINANTS AND TO RECOMBINANT VACCINES IN ITALY

被引：6
|
作者：
ZANETTI, AR
TANZI, E
ROMANO, L
VIGANO, P
CARGNEL, A
HOJVAT, S
ZUCKERMAN, AJ
机构：
[1] ROYAL FREE HOSP,SCH MED,WHO COLLABORATING CTR REFERENCE & RES VIRAL DIS,OFF DEAN,LONDON NW3 2PF,ENGLAND
[2] UNIV MILAN,INST VIROL,I-20122 MILAN,ITALY
[3] HOSP L SACCO,DIV INFECT DIS 2,MILAN,ITALY
[4] ABBOTT LABS,N CHICAGO,IL 60064
来源：
JOURNAL OF MEDICAL VIROLOGY | 1990年 / 32卷 / 04期
关键词：
HEPATITIS-B GROUP DETERMINANT-A; SUBTYPE DETERMINANTS; RECOMBINANT VACCINES;
D O I：
10.1002/jmv.1890320405
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The kinetics of antibody response to the group determinant a and subdeterminants d and y of hepatitis B virus were studied after infection and following immunisation with two recombinant DNA yeast-derived hepatitis B vaccines. The initial antibody response was to the subdeterminant epitopes, whereas anti-a antibody, which provides protection against different subtypes of the virus, was not detected for some weeks or months. The delay in the development of anti-a antibody after active immunisation raises important issues of early protection against infection.
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页码：219 / 224
页数：6
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