Unraveling SARS-CoV-2 spike protein activation pathway reveals unprecedented cryptic pockets

被引：0
|
作者：
Dokainish, Hisham M. [1 ]
Re, Suyong [2 ]
Mori, Takaharu [1 ]
Kobayashi, Chigusa [3 ]
Jung, Jaewoon [3 ]
Sugita, Yuji [1 ]
机构：
[1] RIKEN, Wako, Saitama, Japan
[2] Natl Inst Biomed Innovat Hlth & Nutr, Osaka, Japan
[3] RIKEN, Kobe, Hyogo, Japan
来源：
BIOPHYSICAL JOURNAL | 2022年 / 121卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
2208-Pos
引用
收藏
页码：457A / 457A
页数：1
相关论文
共 50 条
  • [1] Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein
    Zuzic, Lorena
    Samsudin, Firdaus
    Shivgan, Aishwary T.
    Raghuvamsi, Palur V.
    Marzinek, Jan K.
    Boags, Alister
    Pedebos, Conrado
    Tulsian, Nikhil K.
    Warwicker, Jim
    MacAry, Paul
    Crispin, Max
    Khalid, Syma
    Anand, Ganesh S.
    Bond, Peter J.
    STRUCTURE, 2022, 30 (08) : 1062 - +
  • [2] Proteolytic activation of SARS-CoV-2 spike protein
    Takeda, Makoto
    MICROBIOLOGY AND IMMUNOLOGY, 2022, 66 (01) : 15 - 23
  • [3] SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome
    Zimmerman, Maxwell, I
    Porter, Justin R.
    Ward, Michael D.
    Singh, Sukrit
    Vithani, Neha
    Meller, Artur
    Mallimadugula, Upasana L.
    Kuhn, Catherine E.
    Borowsky, Jonathan H.
    Wiewiora, Rafal P.
    Hurley, Matthew F. D.
    Harbison, Aoife M.
    Fogarty, Carl A.
    Coffland, Joseph E.
    Fadda, Elisa
    Voelz, Vincent A.
    Chodera, John D.
    Bowman, Gregory R.
    NATURE CHEMISTRY, 2021, 13 (07) : 651 - +
  • [4] SARS-CoV-2 Simulations go Exascale to Capture Spike Opening and Reveal Cryptic Pockets Across the Proteome
    Zimmerman, Maxwell I.
    Bowman, Gregory
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 299A - 299A
  • [5] SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome
    Maxwell I. Zimmerman
    Justin R. Porter
    Michael D. Ward
    Sukrit Singh
    Neha Vithani
    Artur Meller
    Upasana L. Mallimadugula
    Catherine E. Kuhn
    Jonathan H. Borowsky
    Rafal P. Wiewiora
    Matthew F. D. Hurley
    Aoife M. Harbison
    Carl A. Fogarty
    Joseph E. Coffland
    Elisa Fadda
    Vincent A. Voelz
    John D. Chodera
    Gregory R. Bowman
    Nature Chemistry, 2021, 13 : 651 - 659
  • [6] Amyloidogenesis of SARS-CoV-2 Spike Protein
    Nystrom, Sofie
    Hammarstrom, Per
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 144 (20) : 8945 - 8950
  • [7] SARS-CoV-2 and the spike protein in endotheliopathy
    Perico, Luca
    Benigni, Ariela
    Remuzzi, Giuseppe
    TRENDS IN MICROBIOLOGY, 2024, 32 (01) : 53 - 67
  • [8] Structure of SARS-CoV-2 spike protein
    Zhang, Jun
    Xiao, Tianshu
    Cai, Yongfei
    Chen, Bing
    CURRENT OPINION IN VIROLOGY, 2021, 50 : 173 - 182
  • [9] Elucidation of Cryptic and Allosteric Pockets within the SARS-CoV-2 Main Protease
    Sztain, Terra
    Amaro, Rommie
    McCammon, J. Andrew
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2021, 61 (07) : 3495 - 3501
  • [10] Activation Pathways and Free Energy Landscapes of the SARS-CoV-2 Spike Protein
    Wu, Yichao
    Qian, Ruixin
    Yang, Yan
    Sheng, Yuebiao
    Li, Wenfei
    Wang, Wei
    ACS OMEGA, 2021, 6 (36): : 23432 - 23441
12345