INVESTIGATIONS INTO THE BIOEQUIVALENCE OF 2 NIFEDIPINE CONTROLLED-RELEASE FORMULATIONS AFTER SINGLE APPLICATION AND IN STEADY-STATE

被引：0
|
作者：
MEYER, FP
BANDITT, P
机构：
来源：
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1993年 / 43-1卷 / 06期
关键词：
CALCIUM ANTAGONISTS; CAS; 21829-25-4; CORINFAR(R) RETARD; NIFEDIPINE; BIOAVAILABILITY; CONTROLLED-RELEASE FORMULATIONS; PHARMACOKINETICS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The bioequivalence of nifedipine (CAS 21829-25-4) in controlled-release formulation (Corinfar(R) retard dragees) was tested versus a reference preparation in 22 subjects in a cross-over design after the first dose and in steady state. Compared to the reference, the preparations tested were found to have a relative bioavailability of 0.86 and 0.95, respectively. The bioavailability parameters of the preparations tested did not differ from each other In particular, the fluctuation indices were noted to be highly similar In view of the marked prolonged-action effect, a twice-per-day application is possible for the majority of the patients.
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页码：646 / 650
页数：5
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