COMPENSATORY RENAL GROWTH IN HUMAN FETUSES WITH UNILATERAL RENAL AGENESIS

被引：31
|
作者：
HARTSHORNE, N
SHEPARD, T
BARR, M
机构：
[1] UNIV WASHINGTON,DEPT PEDIAT,SEATTLE,WA 98195
[2] UNIV MICHIGAN,DEPT PEDIAT,ANN ARBOR,MI 48109
[3] UNIV MICHIGAN,DEPT PATHOL,ANN ARBOR,MI 48109
来源：
TERATOLOGY | 1991年 / 44卷 / 01期
关键词：
D O I：
10.1002/tera.1420440103
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
To determine whether compensatory growth of the kidney occurs during fetal life we studied 20 human specimens with a unilateral kidney as an isolated defect. The mean combined kidney weight to body weight ratio x 100 in controls was 0.76 +/- 0.14 (SD) and in the solitary kidney cases (after doubling the kidney weight) was 1.26 +/- 0.35 (SD). This significant increase leads us to hypothesize that the increased weight may be due to an induced negative feedback system involving a renotropic factor. From histologic studies a uniform increase in all nephron elements was found. Why should a fetus with adequate placental clearance of metabolic wastes need increased renal size?
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页码：7 / 10
页数：4
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