THERMAL-PROPERTIES AND MECHANICAL-STRESS OF BETA-CYCLODEXTRIN

A comprehensive picture of the thermal behaviour of beta-cyclodextrin was obtained from experiments involving differential scanning calorimetry (DSC), thermogravimetry (TG), thermomechanical analysis (TMA), and hot stage microscopy (HSM). X-ray powder diffractometry (XRD) was used as a complementary technique to detect solid-solid phase transitions of beta-cyclodextrin. Untreated and handled (recrystallized from water, ground, or compacted) samples of commercial beta-cyclodextrin showed different thermodynamic and thermomechanical properties. This should be taken into account when beta-cyclodextrin is used as a pharmaceutical excipient, particularly in tablet technology, since the physical state and the bulk properties of the powder material may be one of the important factors influencing the characteristics of the dosage form.