DRUG-INDUCED PSYCHOSIS IN PARKINSONS-DISEASE .2. ATYPICAL NEUROLEPTICS

被引：0

作者：

WOLTERS, EC

TISSINGH, G

KUIPER, MA

ZWAAN, WA

HORSTINK, MWIM

机构：

[1] FREE UNIV AMSTERDAM,AFDELING NEUROL,ACAD ZIEKENHUIS,1007 MC AMSTERDAM,NETHERLANDS

[2] FREE UNIV AMSTERDAM,ACAD ZIEKENHUIS,AFDELING PSYCHIAT,1007 MC AMSTERDAM,NETHERLANDS

[3] ACAD ZIEKENHUIS NIJMEGEN,AFDELING NEUROL,NIJMEGEN,NETHERLANDS

来源：

ACTA NEUROPSYCHIATRICA | 1994年 / 6卷 / 03期

关键词：

PARKINSONS DISEASE; DOPAMINE; PSYCHOSIS; ATYPICAL NEUROLEPTICS; CLOZAPINE;

D O I：

10.1017/S0924270800033664

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this second part of a review on drug-induced psychosis in Parkinson's disease, the characteristics of typical and atypical neutroleptics will be compared and the therapeutic efficacy and the extrapyramidal side-effects of 'atypical' antipsychotic drugs will be discussed. These drugs affect serotonergic, adrenergic as well as dopaminergic neurotransmission and are best distinguished from the typical neuroleptics on the basis of the relationship between strong 5-HT2 and weak D2 affinities. Their succes may rely on this spectrum of effects. Clozapine, being the first choice, will be discussed in more detail.

引用

页码：43 / 47

页数：5

共 50 条

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